|Application ||WB, E|
|Calculated MW||19843 Da|
|Antigen Region||88-115 aa|
|Other Names||Interleukin-26, IL-26, Protein AK155, IL26, AK155|
|Target/Specificity||This IL26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-115 amino acids from the Central region of human IL26.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL26 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.|
|Tissue Location||Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
IL26 is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.
?Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
?Silverberg, M.S., et al. Nat. Genet. 41(2):216-220(2009)
?Kantarci, O.H., et al. Arch. Neurol. 65(3):349-357(2008)
?Hor, S., et al. J. Biol. Chem. 279(32):33343-33351(2004)
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