|Application ||WB, E|
|Calculated MW||19843 Da|
|Antigen Region||88-115 aa|
|Other Names||Interleukin-26, IL-26, Protein AK155, IL26, AK155|
|Target/Specificity||This IL26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-115 amino acids from the Central region of human IL26.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL26 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.|
|Tissue Location||Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IL26 is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.
?Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
?Silverberg, M.S., et al. Nat. Genet. 41(2):216-220(2009)
?Kantarci, O.H., et al. Arch. Neurol. 65(3):349-357(2008)
?Hor, S., et al. J. Biol. Chem. 279(32):33343-33351(2004)
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