|Application ||WB, E|
|Calculated MW||27751 Da|
|Antigen Region||91-119 aa|
|Other Names||Inhibitor of growth protein 5, p28ING5, ING5|
|Target/Specificity||This ING5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human ING5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||ING5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.|
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Provided below are standard protocols that you may find useful for product applications.
ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq].
Ullah, M., et al. Mol. Cell. Biol. 28(22):6828-6843(2008)
Champagne, K.S., et al. Proteins 72(4):1371-1376(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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