ING5 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8WYH8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27751 Da |
Antigen Region | 91-119 aa |
Gene ID | 84289 |
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Other Names | Inhibitor of growth protein 5, p28ING5, ING5 |
Target/Specificity | This ING5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human ING5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ING5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ING5 |
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Function | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). |
Cellular Location | Nucleus. Chromosome. Note=Localizes to transcription start sites. |
Tissue Location | Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq].
References
Ullah, M., et al. Mol. Cell. Biol. 28(22):6828-6843(2008)
Champagne, K.S., et al. Proteins 72(4):1371-1376(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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