|Application ||WB, E|
|Other Accession||Q63198, P12960, Q28106|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||113320 Da|
|Antigen Region||635-662 aa|
|Other Names||Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1|
|Target/Specificity||This CNTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the Central region of human CNTN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNTN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side|
|Tissue Location||Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CNTN1 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Compton, A.G., et al. Am. J. Hum. Genet. 83(6):714-724(2008)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008)
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