|Application ||WB, IF, E|
|Calculated MW||80474 Da|
|Antigen Region||527-556 aa|
|Other Names||4-alpha-glucan-branching enzyme, Brancher enzyme, Glycogen-branching enzyme, GBE1|
|Target/Specificity||This GBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the Central region of human GBE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GBE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.|
|Tissue Location||Highest levels found in liver and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
GBE1 is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen's disease).
Konstantinidou, A.E., et al. Placenta 29(4):378-381(2008)
Massa, R., et al. Muscle Nerve 37(4):530-536(2008)
Bruno, C., et al. Acta Myol 26(1):75-78(2007)
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