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HES6 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HES6 Antibody (N-term) AP9509A
    Western blot analysis of HES6 Antibody (N-term) (Cat. #AP9509a) in MCF-7 cell line lysates (35ug/lane). HES6 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96HZ4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 24129 Da
Antigen Region 6-34 aa
Additional Information
Gene ID 55502
Other Names Transcription cofactor HES-6, C-HAIRY1, Class B basic helix-loop-helix protein 41, bHLHb41, Hairy and enhancer of split 6, HES6 {ECO:0000312|EMBL:AAK516341}, BHLHB41
Target/Specificity This HES6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human HES6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHES6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HES6 {ECO:0000312|EMBL:AAK51634.1}
Synonyms BHLHB41
Function Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

HES6 is a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. The protein functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus.

References

lubb, D.M., et al. Neurosci. Lett. 460(2):185-190(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Eun, B., et al. J. Biol. Chem. 283(9):5939-5949(2008)
Scheffer, D., et al. FEBS Lett. 581(24):4651-4656(2007)

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$ 295.00
$ 99.00
Cat# AP9509A
Size:
Quantity:
(40 western blots)
Availability: In Stock
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