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HES6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96HZ4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24129 Da |
| Antigen Region | 6-34 aa |
| Gene ID | 55502 |
|---|---|
| Other Names | Transcription cofactor HES-6, C-HAIRY1, Class B basic helix-loop-helix protein 41, bHLHb41, Hairy and enhancer of split 6, HES6 {ECO:0000312|EMBL:AAK516341}, BHLHB41 |
| Target/Specificity | This HES6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human HES6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HES6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HES6 {ECO:0000312|EMBL:AAK51634.1} |
|---|---|
| Synonyms | BHLHB41 |
| Function | Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HES6 is a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. The protein functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus.
References
lubb, D.M., et al. Neurosci. Lett. 460(2):185-190(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Eun, B., et al. J. Biol. Chem. 283(9):5939-5949(2008)
Scheffer, D., et al. FEBS Lett. 581(24):4651-4656(2007)
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