HS3ST2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9Y278 |
Other Accession | Q80W66, Q673U1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 41501 Da |
Antigen Region | 317-346 aa |
Gene ID | 9956 |
---|---|
Other Names | Heparan sulfate glucosamine 3-O-sulfotransferase 2, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, 3-OST-2, Heparan sulfate 3-O-sulfotransferase 2, h3-OST-2, HS3ST2, 3OST2 |
Target/Specificity | This HS3ST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human HS3ST2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HS3ST2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HS3ST2 |
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Synonyms | 3OST2 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:9988768). Catalyzes the O-sulfation of glucosamine in GlcA2S- GlcNS (PubMed:9988768). Unlike HS3ST1/3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity.
References
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Nat. Genet. 41(7):824-828(2009)
Mochizuki, H., et al. J. Biol. Chem. 283(45):31237-31245(2008)
Lawrence, R., et al. Matrix Biol. 26(6):442-455(2007)
O'Donnell, C.D., et al. Virology 346(2):452-459(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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