|Application ||WB, IHC-P, FC, E|
|Other Accession||Q80W66, Q673U1|
|Calculated MW||41501 Da|
|Antigen Region||317-346 aa|
|Other Names||Heparan sulfate glucosamine 3-O-sulfotransferase 2, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, 3-OST-2, Heparan sulfate 3-O-sulfotransferase 2, h3-OST-2, HS3ST2, 3OST2|
|Target/Specificity||This HS3ST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human HS3ST2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HS3ST2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity.
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Nat. Genet. 41(7):824-828(2009)
Mochizuki, H., et al. J. Biol. Chem. 283(45):31237-31245(2008)
Lawrence, R., et al. Matrix Biol. 26(6):442-455(2007)
O'Donnell, C.D., et al. Virology 346(2):452-459(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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