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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LFNG Antibody (Center)   

LFNG Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LFNG Antibody (Center) AP9524c
    LFNG Antibody (Center) (Cat. #AP9524c) western blot analysis in HL-60,K562,Hela cell line lysates (35ug/lane).This demonstrates the LFNG antibody detected the LFNG protein (arrow).
  • IHC-P - LFNG Antibody (Center) AP9524c
    LFNG Antibody (Center)(Cat. #AP9524c) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LFNG Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - LFNG Antibody (Center) AP9524c
    LFNG Antibody (Center) (Cat. #AP9524c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NES3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41773 Da
Antigen Region 86-114 aa
Additional Information
Gene ID 3955
Other Names Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG
Target/Specificity This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLFNG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity).
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).


Dunwoodie, S.L. Biochim. Biophys. Acta 1792(2):100-111(2009)
Reedijk, M., et al. Int. J. Oncol. 33(6):1223-1229(2008)
Sparrow, D.B., et al. Am. J. Hum. Genet. 78(1):28-37(2006)
Cole, S.E., et al. Dev. Cell 3(1):75-84(2002)
Moran, J.L., et al. Mamm. Genome 10(6):535-541(1999)

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$ 295.00
$ 99.00
Cat# AP9524c
(40 western blots)
Availability: In Stock
Bulk Size
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