|Application ||WB, IHC-P, E|
|Calculated MW||37552 Da|
|Antigen Region||80-107 aa|
|Other Names||Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MAT II beta, Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase, MAT2B, TGR|
|Target/Specificity||This MAT2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human MAT2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAT2B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
MAT2B belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT.
Martinez, C.A., et al. Am. J. Obstet. Gynecol. 201 (4), 394 (2009) :
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Attia, R.R., et al. J. Biol. Chem. 283(45):30788-30795(2008)
Wang, Q., et al. World J. Gastroenterol. 14(29):4633-4642(2008)
LeGros, L., et al. J. Biol. Chem. 276(27):24918-24924(2001)
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