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PLA1A Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PLA1A Antibody (Center) AP9548c
    PLA1A Antibody (Center) (Cat. #AP9548c) western blot analysis in mouse liver tissue and CEM cell line lysates (35ug/lane).This demonstrates the PLA1A antibody detected the PLA1A protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q53H76
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 49715 Da
Antigen Region 329-358 aa
Additional Information
Gene ID 51365
Other Names Phospholipase A1 member A, 311-, Phosphatidylserine-specific phospholipase A1, PS-PLA1, PLA1A, NMD, PSPLA1
Target/Specificity This PLA1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the Central region of human PLA1A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLA1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA1A (HGNC:17661)
Synonyms NMD, PSPLA1
Function Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1- acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:P97535}.
Tissue Location Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
Research Areas
Citations (0)
citation

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Background

Phosphatidylserine-specific phospholipase A1-alpha (PLA1A) acts specifically on phosphatidylserine (PS) and 1-acyl-2-lysophosphatidylserine (lyso-PS) to hydrolyze fatty acids at the sn-1 position of these phospholipids.

References

?Morikawa, R.K., et al. J. Biol. Chem. 284(39):26620-26630(2009)
?Aoki, J., et al. Biochim. Biophys. Acta 1582 (1-3), 26-32 (2002) :
?Wang, J., et al. J. Hum. Genet. 47(11):611-613(2002)
?Nagai, Y., et al. J. Biol. Chem. 274(16):11053-11059(1999)
?van Groningen, J.J., et al. FEBS Lett. 404(1):82-86(1997)

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$ 182.50
$ 70.00
Cat# AP9548c
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