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NUPL2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15504 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44872 Da |
| Antigen Region | 88-115 aa |
| Gene ID | 11097 |
|---|---|
| Other Names | Nucleoporin-like protein 2, NLP-1, NUP42 homolog, Nucleoporin hCG1, NUPL2, CG1 |
| Target/Specificity | This NUPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-115 amino acids from the N-terminal region of human NUPL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NUPL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUP42 (HGNC:17010) |
|---|---|
| Synonyms | CG1, NUPL2 |
| Function | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. |
| Cellular Location | Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Excluded from the nucleolus |
| Tissue Location | Ubiquitously expressed. |
Provided below are standard protocols that you may find useful for product applications.
Background
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.
References
?Kendirgi, F., et al. Mol. Biol. Cell 16(9):4304-4315(2005)
?Sasaki, M., et al. Genomics 85(5):641-653(2005)
?Le Rouzic, E., et al. J. Biol. Chem. 277(47):45091-45098(2002)
?de Noronha, C.M., et al. Science 294(5544):1105-1108(2001)
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