|Application ||WB, E|
|Calculated MW||50933 Da|
|Antigen Region||449-478 aa|
|Other Names||NADPH oxidase activator 1, NOX activator 1, Antigen NY-CO-31, NCF2-like protein, P67phox-like factor, p51-nox, NOXA1, P51NOX|
|Target/Specificity||This NOXA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-478 amino acids from the C-terminal region of human NOXA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOXA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1|
|Tissue Location||Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). The NOX activator NOXA1 can stimulate both NOX1 (MIM 300225) and NOX2 (CYBB; MIM 300481), but it appears to be more effective in activating NOX1 (Opitz et al., 2007 [PubMed 17189823]).[supplied by OMIM].
?Niu, X.L., et al. Circulation 121(4):549-559(2010)
?Pacquelet, S., et al. J. Biol. Chem. 283(36):24649-24658(2008)
?Honjo, T., et al. Endothelium 15(3):137-141(2008)
?Kim, J.S., et al. J. Biol. Chem. 282(48):34787-34800(2007)
?Valente, A.J., et al. Free Radic. Biol. Med. 43(3):384-396(2007)
?Cheng, G., et al. J. Biol. Chem. 281(26):17718-17726(2006)
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