|Application ||WB, E|
|Other Accession||Q8VC48, A4FUD4|
|Calculated MW||40797 Da|
|Antigen Region||131-158 aa|
|Other Names||Peroxisome assembly protein 12, Peroxin-12, Peroxisome assembly factor 3, PAF-3, PEX12, PAF3|
|Target/Specificity||This PEX12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the Central region of human PEX12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PEX12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for protein import into peroxisomes.|
|Cellular Location||Peroxisome membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle.
Zeharia, A., et al. J. Hum. Genet. 52(7):599-606(2007)
Mano, S., et al. Plant J. 47(4):604-618(2006)
Gootjes, J., et al. Hum. Mutat. 24(2):130-139(2004)
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