|Application ||WB, E|
|Calculated MW||22077 Da|
|Antigen Region||171-197 aa|
|Other Names||Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8|
|Target/Specificity||This CLDN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-197 amino acids from the C-terminal region of human CLDN4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CPER, CPETR1, WBSCR8|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CLDN4 is an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life.
Papageorgis, P., et al. Cancer Res. 70(3):968-978(2010)
Kimura, J., et al. J. Biol. Chem. 285(1):401-408(2010)
Robertson, S.L., et al. Infect. Immun. 78(1):505-517(2010)
Seckin, Y., et al. Acta Gastroenterol. Belg. 72(4):407-412(2009)
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