|Application ||WB, E|
|Calculated MW||86720 Da|
|Antigen Region||388-414 aa|
|Other Names||Centromere protein I, CENP-I, FSH primary response protein 1, Follicle-stimulating hormone primary response protein, Interphase centromere complex protein 19, Leucine-rich primary response protein 1, CENPI, FSHPRH1, ICEN19, LRPR1|
|Target/Specificity||This CENPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 388-414 amino acids from the Central region of human CENPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CENPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FSHPRH1, ICEN19, LRPR1|
|Function||Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.|
|Cellular Location||Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex|
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Provided below are standard protocols that you may find useful for product applications.
CENPI is involved in the response of gonadal tissues to follicle-stimulating hormone.
Cheeseman, I.M., et al. Mol. Biol. Cell 19(2):587-594(2008)
Izuta, H., et al. Genes Cells 11(6):673-684(2006)
Okada, M., et al. Nat. Cell Biol. 8(5):446-457(2006)
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