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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ZNF451 Antibody (N-term)   

ZNF451 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZNF451 Antibody (N-term) AP9637a
    Western blot analysis of ZNF451 Antibody (N-term) (Cat. #AP9637a) in mouse NIH-3T3 cell line lysates (35ug/lane). ZNF451 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y4E5
Other Accession Q8C0P7
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 121484 Da
Antigen Region 81-110 aa
Additional Information
Gene ID 26036
Other Names Zinc finger protein 451, Coactivator for steroid receptors, ZNF451, COASTER, KIAA0576, KIAA1702
Target/Specificity This ZNF451 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human ZNF451.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZNF451 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF451
Synonyms COASTER {ECO:0000303|Ref.1}, KIAA0576, K
Function E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300- mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).
Cellular Location Nucleus. Nucleus, PML body. Nucleus, nucleoplasm Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location.
Research Areas
Citations (0)

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ZNF451 may be involved in transcriptional regulation. Coactivator for steroid receptors


Karvonen, U., et al. J. Mol. Biol. 382(3):585-600(2008)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 295.00
$ 99.00
Cat# AP9637a
(40 western blots)
Availability: In Stock
Bulk Size
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