|Application ||WB, E|
|Calculated MW||59346 Da|
|Antigen Region||364-392 aa|
|Other Names||Tubulin-specific chaperone E, Tubulin-folding cofactor E, TBCE|
|Target/Specificity||This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 amino acids from the Central region of human TBCE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBCE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
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Provided below are standard protocols that you may find useful for product applications.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)
Padidela, R., et al. J. Clin. Endocrinol. Metab. 94(8):2686-2691(2009)
Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009)
Jin, S., et al. Development 136(9):1571-1581(2009)
Diaz, G.A., et al. Genomics 54(1):13-18(1998)
Parvari, R., et al. Am. J. Hum. Genet. 63(1):163-169(1998)
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