GGCT Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75223 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21008 Da |
Antigen Region | 139-168 aa |
Gene ID | 79017 |
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Other Names | Gamma-glutamylcyclotransferase, Cytochrome c-releasing factor 21, GGCT, C7orf24, CRF21 |
Target/Specificity | This GGCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the C-terminal region of human GGCT. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GGCT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GGCT (HGNC:21705) |
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Synonyms | C7orf24, CRF21 |
Function | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). |
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Provided below are standard protocols that you may find useful for product applications.
Background
GGCT (EC 2.3.2.4) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis.
References
Oakley, A.J., et al. J. Biol. Chem. 283(32):22031-22042(2008)
Bae, E., et al. Proteins 70(2):588-591(2008)
Masuda, Y., et al. Biochem. Biophys. Res. Commun. 346(2):454-460(2006)
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