|Application ||WB, E|
|Calculated MW||46189 Da|
|Antigen Region||353-382 aa|
|Other Names||Protein O-glucosyltransferase 1, 241-, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase, POGLUT1, C3orf9, CLP46, KTELC1, MDSRP|
|Target/Specificity||This KTEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-382 amino acids from the C-terminal region of human KTEL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KTEL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C3orf9, CLP46, KTELC1, MDSRP|
|Function||Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Karadonta, A.V., et al. Int J Immunopathol Pharmacol 22(3):787-793(2009)
Teng, Y., et al. Gene 371(1):7-15(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.