|Application ||WB, IF, E|
|Other Accession||P00398, P05503, O79429, O79876, P00397, Q9MIY8, P18943, P00396, P48659, O78749|
|Predicted||Bovine, Chicken, Zebrafish, Mouse, Pig, Rabbit, Rat, Xenopus|
|Calculated MW||57041 Da|
|Antigen Region||195-224 aa|
|Other Names||Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I, MT-CO1, COI, COXI, MTCO1|
|Target/Specificity||This COXI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human COXI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COXI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||COI, COXI, MTCO1|
|Function||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
# Andrews, R.M., et al. Nat. Genet. 23 (2), 147 (1999) # Anderson, S., et al. Nature 290(5806):457-465(1981)
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