|Application ||WB, IHC-P, FC, E|
|Calculated MW||12722 Da|
|Antigen Region||11-40 aa|
|Other Names||Oxytocin-neurophysin 1, OT-NPI, Oxytocin, Ocytocin, Neurophysin 1, OXT, OT|
|Target/Specificity||This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the Central region of human NEU1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NEU1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neurophysin 1 specifically binds oxytocin.|
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Provided below are standard protocols that you may find useful for product applications.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
Rao, V.V., et al. Cytogenet. Cell Genet. 61(4):271-273(1992)
Ivell, R., et al. Endocrinology 127(6):2990-2996(1990)
Wood, S.P., et al. Science 232(4750):633-636(1986)
Sausville, E., et al. J. Biol. Chem. 260(18):10236-10241(1985)
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