|Application ||WB, FC, E|
|Other Accession||Q8CG72, Q3SYV9|
|Calculated MW||38947 Da|
|Antigen Region||87-114 aa|
|Other Names||Poly(ADP-ribose) glycohydrolase ARH3, ADP-ribosylhydrolase 3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, ADPRHL2, ARH3|
|Target/Specificity||This ADPRHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-114 amino acids from the N-terminal region of human ADPRHL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADPRHL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.|
|Cellular Location||Cytoplasm. Mitochondrion matrix. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
ADPRHL2 is a member of the ADP-ribosylglycohydrolase family. The enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.
Niere, M., et al. Mol. Cell. Biol. 28(2):814-824(2008)
Ono, T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(45):16687-16691(2006)
Mueller-Dieckmann, C., et al. Proc. Natl. Acad. Sci. U.S.A. 103(41):15026-15031(2006)
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