|Application ||WB, IHC-P, FC, E|
|Calculated MW||29643 Da|
|Antigen Region||159-188 aa|
|Other Names||Uroplakin-1b, UP1b, Tetraspanin-20, Tspan-20, Uroplakin Ib, UPIb, UPK1B, TSPAN20|
|Target/Specificity||This UPK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-188 amino acids from the Central region of human UPK1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UPK1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Bladder epithelium.|
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Provided below are standard protocols that you may find useful for product applications.
UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Kalma, Y., et al. Fertil. Steril. 91(4):1042-1049(2009)
Cowled, P., et al. Neoplasia 7(12):1091-1103(2005)
Varga, A.E., et al. Neoplasia 6(2):128-135(2004)
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