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PDE6C Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P51160 |
| Other Accession | Q91ZQ1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99147 Da |
| Antigen Region | 271-300 aa |
| Gene ID | 5146 |
|---|---|
| Other Names | Cone cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha', cGMP phosphodiesterase 6C, PDE6C, PDEA2 |
| Target/Specificity | This PDE6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human PDE6C. |
| Dilution | IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE6C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE6C |
|---|---|
| Synonyms | PDEA2 |
| Function | As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
Provided below are standard protocols that you may find useful for product applications.
Background
PDE6C is the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa.
References
Muradov, H., et al. J. Biol. Chem. 284(47):32662-32669(2009) Chang, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19581-19586(2009) Thiadens, A.A., et al. Am. J. Hum. Genet. 85(2):240-247(2009)
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