|Application ||WB, IHC-P, FC, E|
|Other Accession||P58366, Q9JHZ2|
|Calculated MW||54241 Da|
|Antigen Region||464-492 aa|
|Other Names||Progressive ankylosis protein homolog, ANK, ANKH, KIAA1581|
|Target/Specificity||This ANKH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-492 amino acids from the C-terminal region of human ANKH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANKH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Found in osteoblasts from mandibular bone and from iliac bone; not detected in osteoclastic cells|
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Provided below are standard protocols that you may find useful for product applications.
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
Wang, J., et al. J. Rheumatol. 36(6):1265-1272(2009)
Ho, A.M., et al. Science 289(5477):265-270(2000)
Rojas, K., et al. Genomics 62(2):177-183(1999)
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