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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   PRUNE Antibody (C-term)   

PRUNE Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PRUNE Antibody (C-term) AP9748b
    Western blot analysis of PRUNE Antibody (C-term) (Cat. #AP9748b) in Jurkat cell line lysates (35ug/lane). PRUNE (arrow) was detected using the purified Pab.
  • IHC-P - PRUNE Antibody (C-term) AP9748b
    PRUNE Antibody (C-term) (Cat. #AP9748b) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRUNE Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - PRUNE Antibody (C-term) AP9748b
    PRUNE Antibody (C-term) (Cat. #AP9748b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86TP1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50200 Da
Antigen Region 360-389 aa
Additional Information
Gene ID 58497
Other Names Protein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE
Target/Specificity This PRUNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the C-terminal region of human PRUNE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRUNE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Cellular Location Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed
Tissue Location Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas
Research Areas
Citations (0)

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Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. It plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.


Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Middelhaufe, S., et al. Biochem. J. 407(2):199-205(2007)
Kobayashi, T., et al. Mol. Cell. Biol. 26(3):898-911(2006)
Zollo, M., et al. Clin. Cancer Res. 11(1):199-205(2005)
Forus, A., et al. Oncogene 20(47):6881-6890(2001)
Reymond, A., et al. Oncogene 18(51):7244-7252(1999)

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$ 295.00
$ 99.00
Cat# AP9748b
(40 western blots)
Availability: In Stock
Bulk Size
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