|Application ||WB, E|
|Other Accession||P49743, P28704, Q05343, P28700, P19793|
|Calculated MW||56922 Da|
|Antigen Region||256-284 aa|
|Other Names||Retinoic acid receptor RXR-beta, Nuclear receptor subfamily 2 group B member 2, Retinoid X receptor beta, RXRB, NR2B2|
|Target/Specificity||This RXRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-284 amino acids from the Central region of human RXRB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RXRB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).|
|Tissue Location||Expressed in a variety of tumor cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009)
Kalsch, A.I., et al. Autoimmunity 42(5):467-474(2009)
Andreotti, G., et al. Eur. J. Epidemiol. 24(12):763-774(2009)
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