|Application ||WB, IHC-P, FC, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||87991 Da|
|Antigen Region||93-121 aa|
|Other Names||ATP-dependent RNA helicase SUPV3L1, mitochondrial, Suppressor of var1 3-like protein 1, SUV3-like protein 1, SUPV3L1, SUV3|
|Target/Specificity||This SUPV3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human SUPV3L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||SUPV3L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.|
|Cellular Location||Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
SUV3L1 is an ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. It may protect cells from apoptosis.
Szczesny, R.J., et al. Nucleic Acids Res. 38(1):279-298(2010)
Wang, D.D., et al. J. Biol. Chem. 284(31):20812-20821(2009)
Khidr, L., et al. J. Biol. Chem. 283(40):27064-27073(2008)
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)
Pereira, M., et al. Mech. Ageing Dev. 128 (11-12), 609-617 (2007)
Shu, Z., et al. Biochemistry 43(16):4781-4790(2004)
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