|Application ||WB, IHC-P, FC, IF, E|
|Calculated MW||74720 Da|
|Antigen Region||342-370 aa|
|Other Names||Zinc finger protein 202, Zinc finger protein with KRAB and SCAN domains 10, ZNF202, ZKSCAN10|
|Target/Specificity||This ZNF202 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-370 amino acids from the Central region of human ZNF202.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF202 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.|
|Tissue Location||Highly expressed in testis. Also expressed in breast carcinoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
ZNF202 (Zinc finger protein 202) is a transcriptional repressor of genes affecting the vascular endothelium as well as lipid metabolism and energy homeostasis. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.
Aberg, K., et al. Biol. Psychiatry 67(3):279-282(2010)
Drenos, F., et al. Hum. Mol. Genet. 18(12):2305-2316(2009)
Patterson, E.S., et al. Physiol. Genomics 34(3):277-284(2008)
Stene, M.C., et al. J. Am. Coll. Cardiol. 52(5):369-377(2008)
Stene, M.C., et al. J. Lipid Res. 47(5):944-952(2006)
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