|Application ||WB, IHC-P, FC, E|
|Other Accession||P38407, P20612, P04695|
|Calculated MW||40041 Da|
|Antigen Region||290-318 aa|
|Other Names||Guanine nucleotide-binding protein G(t) subunit alpha-1, Transducin alpha-1 chain, GNAT1, GNATR|
|Target/Specificity||This GNAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the C-terminal region of human GNAT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNAT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.|
|Tissue Location||Rod. Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium|
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Provided below are standard protocols that you may find useful for product applications.
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells.
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Szabo, V., et al. Hum. Mutat. 28(7):741-742(2007)
Yi, H.M., et al. Ai Zheng 26(1):9-14(2007)
Oldham, W.M., et al. Nat. Struct. Mol. Biol. 13(9):772-777(2006)
Muzny, D.M., et al. Nature 440(7088):1194-1198(2006)
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