|Application ||WB, IHC-P, E|
|Other Accession||Q64232, Q9CY27, Q3ZCD7|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||36034 Da|
|Antigen Region||268-295 aa|
|Other Names||Very-long-chain enoyl-CoA reductase, Synaptic glycoprotein SC2, Trans-2, 3-enoyl-CoA reductase, TER, TECR, GPSN2, SC2|
|Target/Specificity||This GPSN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human GPSN2.|
|Precautions||GPSN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in most tissues tested. Highly expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Microsomal long and very long chain fatty acid elongation uses malonyl-CoA as the 2-carbon donor and consists of 4 sequential reactions. TER catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA.
Hashmi, G., et al. Transfusion 45(5):680-688(2005)
Moon, Y.A., et al. J. Biol. Chem. 278(9):7335-7343(2003)
Mao, M., et al. Proc. Natl. Acad. Sci. U.S.A. 95(14):8175-8180(1998)
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