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GRPR Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRPR Antibody (Center) AP9790c
    Western blot analysis of GRPR Antibody (Center) (Cat. #AP9790c) in HL-60 cell line lysates (35ug/lane). GRPR (arrow) was detected using the purified Pab.
  • IHC-P - GRPR Antibody (Center) AP9790c
    GRPR Antibody (Center) (Cat. #AP9790c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GRPR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - GRPR Antibody (Center) AP9790c
    GRPR Antibody (Center) (Cat. #AP9790c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30550
Other Accession P52500, P21729
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43199 Da
Antigen Region 123-152 aa
Additional Information
Gene ID 2925
Other Names Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
Target/Specificity This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRPR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain
Research Areas
Citations (0)

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Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.


Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Chao, C., et al. J. Surg. Res. 156(1):26-31(2009)
Ananias, H.J., et al. Prostate 69(10):1101-1108(2009)
Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009)

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Cat# AP9790c
(40 western blots)
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