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HAPLN1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P10915 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40166 Da |
| Antigen Region | 10-38 aa |
| Gene ID | 1404 |
|---|---|
| Other Names | Hyaluronan and proteoglycan link protein 1, Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein, HAPLN1, CRTL1 |
| Target/Specificity | This HAPLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human HAPLN1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HAPLN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HAPLN1 |
|---|---|
| Synonyms | CRTL1 |
| Function | Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Widely expressed. Weakly expressed in the brain. |
Provided below are standard protocols that you may find useful for product applications.
Background
HAPLN1 belongs to the HAPLN family. It contains 1 Ig like V type (immunoglobulin like) domain and 2 Link domains. This protein stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
References
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009)
Cenit, M.D., et al. Mult. Scler. 15(8):913-917(2009)
Ivanova, A.V., et al. Clin. Cancer Res. 15(8):2602-2611(2009)
Murabito, J.M., et al. BMC Med. Genet. 8 SUPPL 1, S6 (2007)
Seyfried, N.T., et al. J. Biol. Chem. 280(7):5435-5448(2005)
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