- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||40166 Da|
|Antigen Region||10-38 aa|
|Other Names||Hyaluronan and proteoglycan link protein 1, Cartilage-linking protein 1, Cartilage-link protein, Proteoglycan link protein, HAPLN1, CRTL1|
|Target/Specificity||This HAPLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human HAPLN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAPLN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed. Weakly expressed in the brain.|
Provided below are standard protocols that you may find useful for product applications.
HAPLN1 belongs to the HAPLN family. It contains 1 Ig like V type (immunoglobulin like) domain and 2 Link domains. This protein stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009)
Cenit, M.D., et al. Mult. Scler. 15(8):913-917(2009)
Ivanova, A.V., et al. Clin. Cancer Res. 15(8):2602-2611(2009)
Murabito, J.M., et al. BMC Med. Genet. 8 SUPPL 1, S6 (2007)
Seyfried, N.T., et al. J. Biol. Chem. 280(7):5435-5448(2005)
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