LMBR1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q6UX01 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55209 Da |
Antigen Region | 462-489 aa |
Gene ID | 55716 |
---|---|
Other Names | Protein LMBR1L, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, Lipocalin-interacting membrane receptor, LMBR1L, KIAA1174, LIMR |
Target/Specificity | This LMBR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-489 amino acids from the C-terminal region of human LMBR1L. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LMBR1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LMBR1L |
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Synonyms | KIAA1174, LIMR |
Function | Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
References
Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)
Fluckinger, M., et al. Biochim. Biophys. Acta 1778(1):342-347(2008)
Zhang, Z., et al. Gene 369, 66-71 (2006) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Wojnar, P., et al. J. Biol. Chem. 278(18):16209-16215(2003)
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