KLC2 Antibody (C-Term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9H0B6 |
Other Accession | NP_073733 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 68935 Da |
Antigen Region | 403-432 aa |
Gene ID | 64837 |
---|---|
Other Names | Kinesin light chain 2, KLC 2, KLC2 |
Target/Specificity | This KLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 403-432 amino acids from the C-terminal region of human KLC2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KLC2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLC2 (HGNC:20716) |
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Function | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). |
Cellular Location | Cytoplasm, cytoskeleton. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio.
References
Trejo, H.E., et al. FASEB J. 24(2):374-382(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
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