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CAPN3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CAPN3 Antibody (C-term) AP9817b
    Western blot analysis of CAPN3 Antibody (C-term) (Cat. #AP9817b) in HL-60 cell line lysates (35ug/lane). CAPN3 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - CAPN3 Antibody (C-term) AP9817b
    CAPN3 Antibody (C-term) (Cat. #AP9817b) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CAPN3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • FC - CAPN3 Antibody (C-term) AP9817b
    CAPN3 Antibody (C-term) (Cat. #AP9817b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, IHC-P, E
Primary Accession P20807
Other Accession Q9GLG7
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 94254 Da
Antigen Region 603-632 aa
Additional Information
Gene ID 825
Other Names Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1
Target/Specificity This CAPN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-632 amino acids from the C-terminal region of human CAPN3.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAPN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPN3 (HGNC:1480)
Synonyms CANP3, CANPL3, NCL1
Function Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329).
Cellular Location Cytoplasm. Nucleus, nucleolus
Tissue Location Isoform I is skeletal muscle specific.
Research Areas
Citations (0)
citation

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Background

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.

References

Charlton, R., et al. Neuromuscul. Disord. 19(7):449-457(2009)
Moretti, D., et al. Carcinogenesis 30(6):960-967(2009)
Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
Beckmann, J.S., et al. Neuromuscul. Disord. 18(12):913-921(2008)
Shirafuji, T., et al. Rinsho Shinkeigaku 48(9):651-655(2008)
Diaz, B.G., et al. J. Biol. Chem. 279(26):27656-27666(2004)

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$ 365.00
$ 140.00
Cat# AP9817b
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