|Application ||WB, IHC-P, FC, E|
|Calculated MW||94254 Da|
|Antigen Region||603-632 aa|
|Other Names||Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1|
|Target/Specificity||This CAPN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-632 amino acids from the C-terminal region of human CAPN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CANP3, CANPL3, NCL1|
|Function||Calcium-regulated non-lysosomal thiol-protease.|
|Tissue Location||Isoform I is skeletal muscle specific.|
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Provided below are standard protocols that you may find useful for product applications.
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.
Charlton, R., et al. Neuromuscul. Disord. 19(7):449-457(2009)
Moretti, D., et al. Carcinogenesis 30(6):960-967(2009)
Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
Beckmann, J.S., et al. Neuromuscul. Disord. 18(12):913-921(2008)
Shirafuji, T., et al. Rinsho Shinkeigaku 48(9):651-655(2008)
Diaz, B.G., et al. J. Biol. Chem. 279(26):27656-27666(2004)
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