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PDK2 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - PDK2 Antibody AP9827a
    PDK2 Antibody (Cat.# AP9827a) western blot analysis in RD cell line and mouse heart,rat heart lysates (35ug/lane).This demonstrates the PDK2 antibody detected the PDK2 protein (arrow).
  • FC - PDK2 Antibody AP9827a
    PDK2 Antibody (Cat. #AP9827a) flow cytometric analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IHC-P - PDK2 Antibody AP9827a
    PDK2 Antibody (Cat. #AP9827a) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PDK2 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15119
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46154 Da
Additional Information
Gene ID 5164
Other Names [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2
Target/Specificity This PDK2 antibody is generated from rabbits immunized with recombinant protein of human PDK2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDK2
Synonyms PDHK2
Function Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
Cellular Location Mitochondrion matrix.
Tissue Location Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung
Research Areas
Citations ( 0 )


PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.


Li, J., et al. J. Biol. Chem. 284(49):34458-34467(2009) Fencl, F., et al. Pediatr. Nephrol. 24(5):983-989(2009) Sun, W., et al. Clin. Cancer Res. 15(2):476-484(2009) Hiromasa, Y., et al. Biochemistry 47(8):2312-2324(2008)

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$ 295.00
$ 99.00
Cat# AP9827a
(40 western blots)
Availability: In Stock
Bulk Size
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