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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ZRANB1 Antibody (C-term)   

ZRANB1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZRANB1 Antibody (C-term) AP9830b
    Western blot analysis of ZRANB1 Antibody (C-term) (Cat. #AP9830b) in K562 cell line lysates (35ug/lane). ZRANB1 (arrow) was detected using the purified Pab.
  • WB - ZRANB1 Antibody (C-term) AP9830b
    Western blot analysis of ZRANB1 Antibody (C-term) (Cat. #AP9830b) in mouse cerebellum tissue lysates (35ug/lane). ZRANB1 (arrow) was detected using the purified Pab.
  • IHC-P - ZRANB1 Antibody (C-term) AP9830b
    ZRANB1 Antibody (C-term) (Cat. #AP9830b) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZRANB1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UGI0
Other Accession Q7M760, A6QP16
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 80967 Da
Antigen Region 665-692 aa
Additional Information
Gene ID 54764
Other Names Ubiquitin thioesterase ZRANB1, TRAF-binding domain-containing protein, hTrabid, Zinc finger Ran-binding domain-containing protein 1, ZRANB1, TRABID
Target/Specificity This ZRANB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 665-692 amino acids from the C-terminal region of human ZRANB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZRANB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TRABID
Function Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
Cellular Location Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm
Tissue Location Widely expressed.
Research Areas
Citations (0)

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ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.


Tran, H., et al. Genes Dev. 22(4):528-542(2008)
Evans, P.C., et al. Biochem. J. 357 (PT 3), 617-623 (2001)

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$ 295.00
$ 99.00
Cat# AP9830b
(40 western blots)
Availability: In Stock
Bulk Size
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