|Application ||WB, IHC-P, E|
|Other Accession||Q7M760, A6QP16|
|Calculated MW||80967 Da|
|Antigen Region||665-692 aa|
|Other Names||Ubiquitin thioesterase ZRANB1, TRAF-binding domain-containing protein, hTrabid, Zinc finger Ran-binding domain-containing protein 1, ZRANB1, TRABID|
|Target/Specificity||This ZRANB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 665-692 amino acids from the C-terminal region of human ZRANB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZRANB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.
Tran, H., et al. Genes Dev. 22(4):528-542(2008)
Evans, P.C., et al. Biochem. J. 357 (PT 3), 617-623 (2001)
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