|Application ||WB, IHC-P, E|
|Calculated MW||31915 Da|
|Antigen Region||228-257 aa|
|Other Names||Claudin-23, CLDN23|
|Target/Specificity||This CLDN23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human CLDN23.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN23 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor|
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Provided below are standard protocols that you may find useful for product applications.
CLDN23 is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. It is a candidate tumor suppressor gene implicated in intestinal-type gastric cancer.
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ballana, E., et al. BMC Med. Genet. 8, 81 (2007) :
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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