|Application ||WB, FC, E|
|Calculated MW||57156 Da|
|Antigen Region||437-463 aa|
|Other Names||Alanine--glyoxylate aminotransferase 2, mitochondrial, AGT 2, (R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBAT, AGXT2, AGT2|
|Target/Specificity||This AGXT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-463 amino acids from the C-terminal region of human AGXT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||AGXT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.
Rodionov, R.N., et al. J. Biol. Chem. 285(8):5385-5391(2010)
Baker, P.R., et al. Am. J. Physiol., Cell Physiol. 287 (5), C1359-C1365 (2004)
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