|Application ||WB, FC, E|
|Calculated MW||37735 Da|
|Antigen Region||298-327 aa|
|Other Names||Organic solute transporter subunit alpha, OST-alpha, Solute carrier family 51 subunit alpha, SLC51A, OSTA|
|Target/Specificity||This OST alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the C-terminal region of human OST alpha.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OST alpha Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes.|
|Tissue Location||Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Renner, O., et al. J. Lipid Res. 49(9):2045-2054(2008)
Soroka, C.J., et al. BMC Cell Biol. 9, 57 (2008)
Sun, A.Q., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6), G1586-G1593 (2007)
Boyer, J.L., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6), G1124-G1130 (2006)
Lim, J., et al. Cell 125(4):801-814(2006)
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