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ETS2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P15036 |
| Other Accession | P15037, A1A4L6 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53001 Da |
| Antigen Region | 146-173 aa |
| Gene ID | 2114 |
|---|---|
| Other Names | Protein C-ets-2, ETS2 |
| Target/Specificity | This ETS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human ETS2. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ETS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ETS2 |
|---|---|
| Function | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
Background
ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
References
Zabuawala, T., et al. Cancer Res. 70(4):1323-1333(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Shalaby, A.A., et al. Mod. Pathol. 22(8):996-1005(2009)
Sutter, W., et al. J Craniomaxillofac Surg 37(5):263-271(2009)
Staun-Ram, E., et al. Reprod. Biol. Endocrinol. 7, 135 (2009)
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