- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Other Accession||P15037, A1A4L6|
|Calculated MW||53001 Da|
|Antigen Region||146-173 aa|
|Other Names||Protein C-ets-2, ETS2|
|Target/Specificity||This ETS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human ETS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.|
Provided below are standard protocols that you may find useful for product applications.
ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
Zabuawala, T., et al. Cancer Res. 70(4):1323-1333(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Shalaby, A.A., et al. Mod. Pathol. 22(8):996-1005(2009)
Sutter, W., et al. J Craniomaxillofac Surg 37(5):263-271(2009)
Staun-Ram, E., et al. Reprod. Biol. Endocrinol. 7, 135 (2009)
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