|Application ||WB, IHC-P, FC, E|
|Calculated MW||40989 Da|
|Antigen Region||230-258 aa|
|Other Names||Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17, P2Y-like receptor, R12, GPR17|
|Target/Specificity||This GPR17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-258 amino acids from the Central region of human GPR17.|
|Precautions||GPR17 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain|
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Members of the G protein coupled receptor (GPCR) superfamily contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The organization of the GPR17 gene differs from that of many other GPCRs in that the open reading frame is distributed on 2 exons; an additional exon contains the 5 prime untranslated region. Human GPR17 is expressed as 2.3 and 6.3 kb mRNAs exclusively in brain. The 2 transcripts appear to represent alternatively polyadenylated variants. Based on protein sequence homology and the conservation of certain key residues, GPR17 appears to be closely related to the P2Y family of GPCRs. There are two nemed isoforms.
Pugliese, A.M., et al. Am. J. Physiol., Cell Physiol. 297 (4), C1028-C1040 (2009)
Parravicini, C., et al. BMC Bioinformatics 9, 263 (2008)
Ciana, P., et al. EMBO J. 25(19):4615-4627(2006)
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