|Application ||WB, FC, E|
|Calculated MW||56866 Da|
|Antigen Region||176-203 aa|
|Other Names||Keratin, type II cytoskeletal 78, Cytokeratin-78, CK-78, Keratin-5b, Keratin-78, K78, Type-II keratin Kb40, KRT78, K5B, KB40|
|Target/Specificity||This K2C78 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-203 amino acids from the Central region of human K2C78.|
|Precautions||K2C78 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in tongue, but not in skin or in any other tissues or organs examined.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
Hesse, M., et al. Eur. J. Cell Biol. 83(1):19-26(2004)
Coulombe, P.A., et al. Curr. Opin. Cell Biol. 14(1):110-122(2002)
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