|Application ||WB, FC, E|
|Calculated MW||67723 Da|
|Antigen Region||261-290 aa|
|Other Names||mRNA-decapping enzyme 1B, 3---, DCP1B|
|Target/Specificity||This DCP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids of human DCP1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCP1B Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay.
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Cougot, N., et al. J. Cell Biol. 165(1):31-40(2004)
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