- CITATIONS: 2
|Application ||WB, IHC-P, FC, E|
|Calculated MW||52658 Da|
|Antigen Region||13-40 aa|
|Other Names||Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2, MARCO, SCARA2|
|Target/Specificity||This MARCO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human MARCO.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MARCO Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
Provided below are standard protocols that you may find useful for product applications.
MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
Wright, A.K., et al. J. Leukoc. Biol. 86(3):479-489(2009)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Arredouani, M.S., et al. J. Immunol. 175(9):6058-6064(2005)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Seta, N., et al. Arthritis Rheum. 44(4):931-939(2001)
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