|Application ||WB, IHC-P, E|
|Other Accession||P24049, Q3T025|
|Calculated MW||21397 Da|
|Antigen Region||156-184 aa|
|Other Names||60S ribosomal protein L17, 60S ribosomal protein L23, PD-1, RPL17|
|Target/Specificity||This RPL17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the C-terminal region of human RPL17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPL17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the large ribosomal subunit.|
|Tissue Location||Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979 Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17.
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Kapp, L.D., et al. Annu. Rev. Biochem. 73, 657-704 (2004)
Mazumder, B., et al. Cell 115(2):187-198(2003)
Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
Odintsova, T.I., et al. J. Protein Chem. 22(3):249-258(2003)
Yoshihama, M., et al. Genome Res. 12(3):379-390(2002)
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