|Application ||WB, E|
|Calculated MW||33972 Da|
|Antigen Region||150-179 aa|
|Other Names||TBC1 domain family member 7, Cell migration-inducing protein 23, TBC1D7, TBC7|
|Target/Specificity||This TBCD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human TBCD7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBCD7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.|
|Cellular Location||Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex|
|Tissue Location||Highly expressed in heart, and slightly in kidney, liver and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
TBC1D7 belongs to the family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2.
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Nakashima, A., et al. Biochem. Biophys. Res. Commun. 361(1):218-223(2007)
Larson, M.G., et al. BMC Med. Genet. 8 SUPPL 1, S5 (2007)
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