|Application ||WB, E|
|Calculated MW||78211 Da|
|Antigen Region||536-565 aa|
|Other Names||Phosphatase and actin regulator 4, PHACTR4|
|Target/Specificity||This PHAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PHAR4.|
|Precautions||PHAR4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).|
|Cellular Location||Cytoplasm. Cell projection, lamellipodium|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Allen, P.B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(18):7187-7192(2004)
Sagara, J., et al. J. Biol. Chem. 278(46):45611-45619(2003)
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