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NMRL1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP9906a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9906a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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NMRL1 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9HBL8 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33344 Da |
NMRL1 Antibody (N-term) - Additional info | |
| Gene ID 57407 | |
| Other Names NMRAL1; HSCARG; NmrA-like family domain-containing protein 1 | |
| Target/Specificity This NMRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29~58 amino acids from the N-terminal region of human NMRL1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NMRL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NMRL1 Antibody (N-term) - Protein Information | |
| Name NMRAL1 | |
| Synonyms HSCARG | |
| Function Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer | |
| Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios | |
NMRL1 Antibody (N-term) - Related products
AP9906a: NMRL1 Antibody (N-term)
NMRL1 Antibody (N-term) - Application data
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Western blot analysis of NMRL1 Antibody (N-term)（Cat. #AP9906a) in A375 cell line lysates (35ug/lane). NMRL1 (arrow) was detected using the purified Pab.
NMRL1 Antibody (N-term) - Research Areas
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REFERENCES
Lian, M., et al. J. Biol. Chem. 284(27):17998-18006(2009) Dai, X., et al. J. Mol. Biol. 387(5):1277-1285(2009) Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) Zhao, Y., et al. J. Biol. Chem. 283(16):11004-11013(2008)
