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CFP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CFP Antibody (Center) AP9941c
    Western blot analysis of CFP Antibody (Center) (Cat. #AP9941c) in CEM cell line lysates (35ug/lane). CFP (arrow) was detected using the purified Pab.
  • FC - CFP Antibody (Center) AP9941c
    CFP Antibody (Center) (Cat. #AP9941c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27918
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51276 Da
Antigen Region 197-223 aa
Additional Information
Gene ID 5199
Other Names Properdin, Complement factor P, CFP, PFC
Target/Specificity This CFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-223 amino acids from the Central region of human CFP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCFP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFP
Synonyms PFC
Function A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Cellular Location Secreted.
Research Areas
Citations (0)

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This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.


Seitsonen, S., et al. Mol. Immunol. 47(6):1334-1336(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29(7):966-973(2009)
Keslar, K., et al. Transplantation 86(9):1319-1321(2008)
Hartmann, S., et al. J. Biol. Chem. 275(37):28569-28574(2000)

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Cat# AP9941c
(40 western blots)
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