|Application ||WB, FC, E|
|Calculated MW||51276 Da|
|Antigen Region||197-223 aa|
|Other Names||Properdin, Complement factor P, CFP, PFC|
|Target/Specificity||This CFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-223 amino acids from the Central region of human CFP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CFP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.
Seitsonen, S., et al. Mol. Immunol. 47(6):1334-1336(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29(7):966-973(2009)
Keslar, K., et al. Transplantation 86(9):1319-1321(2008)
Hartmann, S., et al. J. Biol. Chem. 275(37):28569-28574(2000)
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